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A PROMIS fatigue short form for use by individuals who have multiple sclerosis

Karon F Cook1, Alyssa M Bamer, Toni S Roddey

  • 1Northwestern University, Chicago, IL, USA. karon.cook@northwestern.edu

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
|September 20, 2011
PubMed
Abstract

Insights

A new Patient Reported Outcomes Measurement Information System (PROMIS) fatigue short form for multiple sclerosis (MS) was developed. The PROMIS-Fatigue(MS) shows content validity and accurately measures fatigue in individuals with MS.

Area of Science:

  • Neurology
  • Psychometrics
  • Patient-Reported Outcomes

Background:

  • Fatigue is a significant and common symptom in multiple sclerosis (MS).
  • Existing measures may not fully capture the multifaceted nature of MS-related fatigue.
  • The Patient Reported Outcomes Measurement Information System (PROMIS) offers a robust item bank for developing patient-centered outcome measures.

Purpose of the Study:

  • To derive and validate a new short form measure of fatigue specifically for individuals with multiple sclerosis (MS).
  • To develop the PROMIS-Fatigue(MS) from the PROMIS fatigue item bank.

Main Methods:

  • A panel of clinicians and individuals with MS ranked the relevance of PROMIS fatigue items.
  • Eight highly relevant items were selected for the PROMIS-Fatigue(MS) based on relevance, content coverage, and discrimination.
  • The PROMIS-Fatigue(MS) and PROMIS-Fatigue(SFv1.0) were administered to 231 individuals with MS to assess validity.

Main Results:

  • Scores from the PROMIS-Fatigue(MS) and PROMIS-Fatigue(SFv1.0) were highly correlated (r = 0.92).
  • The PROMIS-Fatigue(MS) demonstrated discriminant validity and better targeted the content of participants' fatigue experiences.
  • No quantitative advantage was found for either short form in this analysis.

Conclusions:

  • The PROMIS-Fatigue(MS) is a valid measure for assessing fatigue in individuals with multiple sclerosis (MS).
  • The measure's items effectively discriminate between groups with differing fatigue levels.
  • The PROMIS-Fatigue(MS) is recommended for use in clinical and research settings to evaluate fatigue in MS.

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