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Related Experiment Video

Updated: May 29, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Fetal hydrocephalus.

Sergio Cavalheiro¹, Antonio Fernandes Moron, Carlos Gilberto Almodin

¹Section of Pediatric Neurosurgery, Federal University of São Paulo, Rua Botucatu 591/42, 04023-062 São Paulo, Brazil. iscava@uol.com.br

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery

|September 20, 2011

Summary

This summary is machine-generated.

Fetal neurosurgery can benefit selected fetuses with hydrocephalus diagnosed before 32 weeks. While outcomes vary, this intrauterine treatment shows no maternal or infectious complications.

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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Area of Science:

Perinatology
Fetal Surgery
Neurodevelopmental Pediatrics

Background:

Hydrocephalus is a frequent and severe fetal illness.
Advanced diagnostics like ultrasonography and MRI aid in early detection.
Fetal Medicine Services are crucial for managing complex pregnancies.

Purpose of the Study:

To evaluate the outcomes of intrauterine treatments for fetal hydrocephalus.
To assess the efficacy of neurosurgical interventions in preventing severe outcomes.
To analyze neurodevelopmental results in children treated in utero.

Main Methods:

Treatment of 57 fetuses with hydrocephalus using cephalocentesis, ventricular-amniotic shunting, and neuroendoscopy.
Open surgical correction for myelomeningocele in 8 fetuses to prevent hydrocephalus.
Long-term follow-up (over 3 years) including intelligence quotient (IQ) assessment.

Main Results:

Of 39 followed patients, 26 had normal IQ, 6 mild/moderate handicaps, and 7 severe handicaps.
Only 2 of 8 myelomeningocele patients required shunting post-correction.
No maternal morbidity or infectious complications were observed in intrauterine treatments.

Conclusions:

Fetal neurosurgical procedures can benefit carefully selected cases of isolated, progressive hydrocephalus diagnosed before 32 weeks.
Improved diagnostic accuracy has reduced the number of eligible patients.
Intrauterine interventions offer a potential treatment pathway with a favorable safety profile.