Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sutures of the Skull

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

Cranial Bones: Superior and Posterior View

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...

Cranial Bones: Lateral View

Cranial Bones: Lateral View

The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...

Cerebral Edema ll: Pathophysiology

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

Neurosurgery·2026

Same author

Percutaneous Vertebral Expansion with the SpineJack Device in Adolescents: A Feasibility Case Series.

Journal of vascular and interventional radiology : JVIR·2026

Same author

Dorsal midline ectopic mammary tissue as a cutaneous marker of spinal dysraphism: intradural lipoma and tethered cord in a child with literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026

Same author

History of Treatment of Pineal Tumors.

Advances and technical standards in neurosurgery·2026

Same author

Decisional Tree for Pineal Tumors.

Advances and technical standards in neurosurgery·2026

Same author

Hydrocephalus Secondary to Pineal Region Lesions.

Advances and technical standards in neurosurgery·2026

Search research articles

Related Experiment Video

Updated: May 29, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Cloverleaf skull deformity and hydrocephalus.

Guilherme Machado¹, Federico Di Rocco, Christian Sainte-Rose

¹Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery

|September 20, 2011

Summary

This summary is machine-generated.

Cloverleaf skull deformity is often linked to hydrocephalus, particularly with bilateral lambdoid stenosis. Treatment requires individualization based on deformity severity and patient comorbidities.

More Related Videos

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Related Experiment Videos

Last Updated: May 29, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

Craniofacial Surgery
Pediatric Neurosurgery
Medical Genetics

Background:

Cloverleaf skull deformity, a rare craniosynostosis, presents with characteristic trigencephaly.
It is frequently associated with significant neurological and developmental challenges, including hydrocephalus.

Purpose of the Study:

To detail the clinical characteristics of operated and non-operated patients with cloverleaf skull deformity.
To investigate the relationship between cloverleaf skull deformity and hydrocephalus, particularly in relation to lambdoid stenosis.

Main Methods:

Retrospective analysis of 13 patients with cloverleaf skull deformity treated between 1977 and 2008.
Evaluation of surgical interventions for craniofacial stenosis and hydrocephalus.

Main Results:

Hydrocephalus was universally present in patients with bilateral lambdoid stenosis.
No hydrocephalus cases were observed in patients with unilateral or absent lambdoid stenosis.
Associated malformations and severe faciostenosis correlated with increased mortality and morbidity.

Conclusions:

Bilateral lambdoid stenosis is strongly associated with the development of hydrocephalus in cloverleaf skull deformity.
Individualized treatment strategies are essential, considering malformation severity and patient comorbidities.