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Severe deterioration of newly diagnosed Takayasu arteritis in a patient re-treated with interferon beta-1α for
Andreas P Diamantopoulos1, Helene Hetland, Atle E Hansen
1Department of Rheumatology, Hospital of Southern Norway, Service box 416, 4604 Kristiansand, Norway. andreas.diamantopoulos@sshf.no
Abstract:
A 52-year-old woman with Takayasu arteritis and a known history of multiple sclerosis had been treated with subcutaneous interferon (IFN) beta-1α. After the re-introduction of the IFN beta-1α, the patient had a gradual worsening of the arteritis, with claudication symptoms in the left arm and increased inflammation markers. An evaluation using Doppler ultrasound of the supra-aortic vessels revealed severe stenosis of the left axillary artery. The IFN beta-1α was withdrawn, with prompt clinical and laboratory improvement of the vasculitis.
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