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Acute change in left ventricle end-diastolic pressure after primary percutaneous coronary intervention in patients

Omer Satıroğlu1, Yüksel Ciçek, Mehmet Bostan

  • 1Cardiology Department, Medical Faculty, Rize University, Turkey. omersatiroglu@yahoo.com

The American Heart Hospital Journal
|September 20, 2011
PubMed

Insights

Primary percutaneous coronary intervention (PCI) rapidly improves left ventricle diastolic function and decreases left ventricle end-diastolic pressure (LVEDP) in ST-segment elevation myocardial infarction (STEMI) patients.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • ST-segment elevation myocardial infarction (STEMI) impairs left ventricle compliance and diastolic function, increasing left ventricle end-diastolic pressure (LVEDP).
  • Primary percutaneous coronary intervention (PCI) is known to acutely impact left ventricle compliance.

Purpose of the Study:

  • To evaluate the effect of primary PCI on left ventricle diastolic function and LVEDP in STEMI patients.
  • To determine if diastolic function improves and LVEDP decreases following PCI in STEMI.

Main Methods:

  • Twenty-nine STEMI patients hospitalized within six hours of symptom onset were enrolled.
  • Coronary angiography (CAG) assessed occluded coronary arteries (RCA, Cx, LAD).
  • Left ventricle end-diastolic pressure (LVEDP) and aortic pressure were measured before and after primary PCI.

Main Results:

  • Successful reperfusion via primary PCI led to significant improvements in left ventricle diastolic function.
  • A significant decrease in mean LVEDP was observed post-PCI in both inferior (5.7 ± 2.9 mmHg) and anterior (4.9 ± 6.5 mmHg) myocardial infarction (MI) patients.
  • Clinical and electrocardiographic (ECG) findings showed rapid improvement.

Conclusions:

  • Primary PCI rapidly enhances LVEDP and diastolic function in both anterior and inferior STEMI.
  • Measuring left ventricular pressure before and after PCI offers a complication-free method for quick assessment of diastolic function improvement.
Abstract

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