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Related Concept Videos

Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
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Diffusion on Chromatography Columns01:07

Diffusion on Chromatography Columns

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Assessment of Diffusion and Perfusion01:17

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Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
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Published on: February 1, 2017

Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studies.

Thomas L Chenevert1, Craig J Galbán, Marko K Ivancevic

  • 1Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA. tlchenev@umich.edu

Journal of Magnetic Resonance Imaging : JMRI
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

A novel ice-water phantom ensures consistent diffusion-weighted MRI (DW-MRI) apparent diffusion coefficient (ADC) measurements across multiple sites. This quality control tool demonstrates excellent inter-system agreement and intra-system reproducibility, vital for multicenter clinical trials.

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Area of Science:

  • Medical Imaging
  • Biomarker Validation
  • Quality Control

Background:

  • Diffusion-weighted magnetic resonance imaging (DW-MRI) is a key candidate for cancer diagnosis and treatment response assessment.
  • Multicenter trials require robust calibration and performance testing of imaging biomarkers across different institutions.

Purpose of the Study:

  • To introduce and evaluate an ice-water phantom for quality control in DW-MRI.
  • To assess the phantom's utility for validating apparent diffusion coefficient (ADC) measurements in multicenter settings.

Main Methods:

  • The phantom design features a distilled water core surrounded by an ice-water bath.
  • DW-MRI data were acquired across seven institutions, involving 20 MRI scanners from three vendors at 1.5T and 3T.
  • Phantom scans were also conducted on a single system over 25 days to assess reproducibility.

Main Results:

  • Apparent diffusion coefficient (ADC) measurements showed excellent agreement between systems, with a variation of ±5%.
  • Single-system reproducibility over 25 days was also within ±5% ADC.
  • The ice-water phantom proved to be a reliable tool for ADC assessment in multicenter trials.

Conclusions:

  • The ice-water phantom offers a practical and universal method for validating ADC measurement accuracy.
  • It is suitable for implementation in multicenter clinical trials, accommodating evolving MRI technology.
  • This phantom aids in standardizing DW-MRI biomarker performance across diverse clinical settings.