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Related Experiment Video

Updated: May 29, 2026

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Telocyte morphologies and potential roles in diseases.

Yonghua Zheng¹, Chunxue Bai, Xiangdong Wang

¹Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of Cellular Physiology

|September 20, 2011

Summary

Telocytes (TCs) are novel interstitial cells identified in the trachea and lung tissues. Further research is needed to understand their role in pulmonary disease pathogenesis.

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Area of Science:

Cell biology
Histology
Pulmonology

Background:

Telocytes (TCs) are a recently discovered type of interstitial cell characterized by unique cellular prolongations called telopodes.
TCs possess distinct morphological and immunophenotypic features, including CD34, c-kit, and vimentin expression.
While found in various mammalian organs, the precise biological functions of TCs remain largely undetermined.

Purpose of the Study:

To identify and isolate telocytes from the trachea.
To confirm the presence of telocytes in lung tissues.
To explore the potential significance of TCs in the pathogenesis of pulmonary diseases.

Main Methods:

Isolation and identification of telocytes from tracheal tissue.
Confirmation of telocyte presence in lung tissues.
Characterization of telocyte morphology and immunophenotype (CD34, c-kit, vimentin).

Main Results:

Telocytes were successfully identified and isolated from the trachea for the first time.
The existence of telocytes in lung tissues was confirmed.
TCs exhibit characteristic features including telopodes, caveolae, and specific immunophenotypes.

Conclusions:

The study confirms the presence of telocytes in the trachea and lung, expanding their known distribution in mammals.
These findings suggest a potential role for telocytes in the pathogenesis of pulmonary diseases.
Further investigation is warranted to elucidate the specific pathophysiological functions of TCs in lung conditions.