Related Experiment Video
Updated: May 29, 2026
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Oral squamous cell carcinoma and a clinically negative neck: the value of follow-up
Bart M Wensing1, Matthias A W Merkx, Paul F M Krabbe
1Department of Otorhinolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. b.wensing@kno.umcn.nl
Background:
In squamous cell carcinoma of the oral cavity (SCCOC), regular follow-up comprises 5 years of prescheduled visits, irrespective of tumor stage/classification and/or treatment. We analyzed our standard treatment and follow-up protocol in patients with a preoperative clinically negative neck (cN0) in SCCOC.
Methods:
This is a retrospective chart analysis. Inventarization of treatment, occult metastatic spread, and follow-up were performed.
Results:
In all, 197 patients were included. The occult metastatic rate was 24%. Eighty-three percent of recurrent disease presented within 2 years. Fifty-three percent of the patients with recurrent disease visited their physician outside prescheduled control visits.
Conclusions:
Ultrasound-guided fine-needle aspiration cytology currently is 1 of the most reliable staging techniques in cN0 SCCOC. Regular follow-up could perhaps be limited from 5 to 2 years of prescheduled follow-up visits.