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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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Published on: March 13, 2013

A surface plasmon resonance sensor on a compact disk-type microfluidic device.

Akihide Hemmi1, Takashi Usui, Akihiro Moto

  • 1Mebius Advanced Technology Ltd., Tokyo, Japan.

Journal of Separation Science
|September 20, 2011
PubMed
Summary

A novel compact disk-type microfluidic device integrates a surface plasmon resonance (SPR) sensor for miniaturized analytical systems. This SPR sensor successfully detected immunoglobulin A (IgA) in an immunoassay.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Microfluidics

Background:

  • Miniaturization of analytical systems is crucial for point-of-care diagnostics.
  • Surface Plasmon Resonance (SPR) offers high sensitivity for biomolecular detection.
  • Integrating SPR with microfluidics on a compact disk (CD) platform presents a novel approach.

Purpose of the Study:

  • To develop a miniaturized, integrated analytical system using a CD-type microfluidic device with an SPR sensor.
  • To demonstrate the feasibility of using centrifugal force for automated sample and reagent handling.
  • To validate the performance of the CD-SPR sensor in a specific immunoassay.

Main Methods:

  • Fabrication of a CD-type microfluidic device using polydimethylsiloxane and polycarbonate disk plates.
  • Utilizing a grating-coupled SPR optical system for detection.
  • Employing centrifugal force generated by CD rotation for sequential introduction of solutions.
  • Performing an immunoassay for immunoglobulin A (IgA) detection.

Main Results:

  • Successful fabrication and integration of SPR sensor on a CD microfluidic platform.
  • Demonstrated automated sequential introduction of reagents and sample via centrifugal force.
  • Achieved successful detection of immunoglobulin A (IgA) through immunoassay.
  • Resonance wavelength variation correlated with refractive index changes.

Conclusions:

  • The developed CD-type microfluidic SPR sensor represents a miniaturized, integrated analytical system.
  • This platform enables automated reagent handling and sensitive biomolecular detection.
  • The system shows promise for various immunoassay applications, including IgA detection.