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Paget's disease of bone.

R L Merkow1, J M Lane

  • 1University of Minnesota Medical School, Minneapolis.

Endocrinology and Metabolism Clinics of North America
|March 1, 1990
PubMed
Summary

Paget's disease of bone involves abnormal bone remodeling, leading to pain and deformities. Treatment focuses on controlling disease activity and improving symptoms, with rare tumor development.

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Area of Science:

  • Orthopedics
  • Endocrinology
  • Pathology

Background:

  • Paget's disease of bone is characterized by accelerated bone remodeling, with initial excessive resorption by osteoclasts followed by compensatory osteoblast activity.
  • The etiology remains largely unknown, though viral infection is a suspected contributing factor.
  • The condition is often asymmetric and can be asymptomatic, presenting with varied clinical and radiographic findings.

Purpose of the Study:

  • To provide a comprehensive overview of Paget's disease of bone, including its pathophysiology, clinical presentation, and management.
  • To highlight the diagnostic challenges and therapeutic strategies for this complex skeletal disorder.

Main Methods:

  • Review of existing literature on Paget's disease of bone.
  • Analysis of clinical and radiographic presentations.
  • Summary of current therapeutic approaches and their objectives.

Main Results:

  • Commonly affects the spine, femora, cranium, pelvis, and sternum.
  • Frequent symptoms include pain, skeletal deformities, and altered skin temperature.
  • Pathologic fractures, particularly in lower extremity long bones, are significant complications.

Conclusions:

  • Therapeutic agents like calcitonins and diphosphonates aim to manage metabolic activity and alleviate symptoms.
  • Early diagnosis is crucial for effective palliation and potentially improving cure rates.
  • Tumors are rare complications, but vigilance is necessary.

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