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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...

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Related Experiment Video

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Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry
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Cellular uptake of elastic nanoparticles.

Xin Yi1, Xinghua Shi, Huajian Gao

  • 1School of Engineering, Brown University, Providence, Rhode Island 02912, USA.

Physical Review Letters
|September 21, 2011
PubMed
Summary

Understanding cell-nanomaterial interactions is crucial for nanomedicine. This study reveals five distinct phases of lipid membrane wrapping of elastic vesicles, depending on size and material properties.

Area of Science:

  • Biophysics
  • Nanotechnology
  • Cell Biology

Background:

  • Cell-nanomaterial interactions are vital for nanomedicine and safe nanotechnology applications.
  • Understanding how cell membranes interact with nanomaterials informs drug delivery and biomedical device design.

Purpose of the Study:

  • To investigate the adhesive wrapping of soft elastic vesicles by lipid membranes.
  • To determine the factors influencing different wrapping states (full, partial, no wrapping).

Main Methods:

  • Theoretical modeling of vesicle-membrane interactions.
  • Analysis of wrapping phases based on vesicle size, adhesion energy, membrane surface tension, and bending rigidity.

Main Results:

  • Identified a maximum of five distinct wrapping phases.

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  • Demonstrated that wrapping phases are contingent upon vesicle size, adhesion energy, surface tension, and bending rigidity ratio.
  • Characterized the stability of full wrapping, partial wrapping, and no wrapping states.

    • Conclusions:

    • Provides a fundamental understanding of cell-nanomaterial interactions at the membrane level.
    • Offers insights into vesicular transport, endocytosis, and phagocytosis of elastic particles.
    • Informs the design and safety assessment of nanomaterials for biomedical applications.