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A new triterpene from Barringtonia asiatica.

Consolacion Y Ragasa1, Dinah L Espineli, Chien-Chang Shen

  • 1Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University 2401 Taft Avenue, Manila 1004, Philippines. consolacion.ragasa@dlsu.edu.ph

Natural Product Research
|September 21, 2011
PubMed
Summary

Barringtonia asiatica yielded a new triterpene and other compounds. These natural products showed slight antimicrobial activity against Candida albicans and Staphylococcus aureus.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Barringtonia asiatica is a plant species with potential medicinal properties.
  • Investigating the chemical constituents of Barringtonia asiatica can lead to the discovery of novel compounds.
  • Understanding the biological activities of these compounds is crucial for potential therapeutic applications.

Purpose of the Study:

  • To isolate and characterize novel and known chemical constituents from the bark, roots, and flowers of Barringtonia asiatica.
  • To evaluate the antimicrobial properties of the isolated compounds against a panel of microorganisms.

Main Methods:

  • Phytochemical investigation involving extraction and isolation techniques.
  • Structure elucidation of isolated compounds using spectroscopic methods.

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  • Antimicrobial susceptibility testing using standard microbiological assays.
  • Main Results:

    • A new triterpene, (3β,11α)-11-hydroxyolean-12-en-3-yl palmitate (1), was isolated from the bark.
    • Several known triterpenes, steroids, and fatty acid esters were identified from different plant parts.
    • Compounds 1-4 and 6 exhibited slight antimicrobial activity against Candida albicans and Staphylococcus aureus.
    • Compounds 3a-c showed slight activity against Pseudomonas aeruginosa.

    Conclusions:

    • Barringtonia asiatica is a rich source of diverse triterpenoids and other phytochemicals.
    • The isolated compounds possess mild antimicrobial properties, suggesting potential for further investigation.
    • This study contributes to the chemotaxonomic understanding of Barringtonia species and their bioactive potential.