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Phadiatop Infant(®) detects IgE-mediated diseases among pre-school children: a prospective study
Caroline Nilsson1, Gunnar Lilja, Monica Nordlund
1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden. caroline.nilsson@sodersjukhuset.se
Insights
Phadiatop Infant (Phinf) effectively detects IgE-sensitization in 5-year-olds. A positive Phinf test in toddlers predicts future allergic sensitization and symptoms in preschool children.
Area of Science:
- Pediatric Allergy and Immunology
- Diagnostic Test Evaluation
Background:
- Immunoglobulin E (IgE) sensitization to allergens can precede allergic disease symptoms.
- Early detection of sensitization is crucial for managing allergic conditions in children.
Purpose of the Study:
- To assess the diagnostic accuracy of Phadiatop Infant (Phinf) for detecting IgE-sensitization at age 5.
- To evaluate the longitudinal predictive value of Phinf for sensitization and allergic symptoms in preschoolers.
Main Methods:
- Evaluated 201 children with data on specific IgE (sIgE) testing, Phinf analysis, and clinical assessments at ages 2 and 5.
- Compared Phinf diagnostic performance against sIgE testing for 10 individual allergens.
Main Results:
- Phinf demonstrated high diagnostic performance at age 5: 84% sensitivity, 98% specificity, 97% positive predictive value, and 92% negative predictive value.
- A positive Phinf test at age 2 significantly increased odds for IgE-sensitization (35.6-fold) and allergic symptoms (14.7-fold) at age 5.
- The association between Phinf and current symptoms strengthened from age 2 (OR 3.6) to age 5 (OR 18.4).
Conclusions:
- Phadiatop Infant (Phinf) is a reliable tool for predicting future IgE-sensitization in young children.
- Phinf also shows predictive capacity for the development of allergic symptoms in preschool-aged children.
Background:
IgE-sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop(®) Infant (Phinf) for detecting IgE-sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre-school children.
Methods:
Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated.
Results:
The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6-fold (95% CI 11.8-107) for IgE-sensitization and 14.7-fold (95% CI 4.4-49.7) for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 (95% CI 1.6-7.9) and 18.4 (95% CI 7.4-45.8), respectively.
Conclusions:
Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children.
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