Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prescription opioid use before and after kidney transplant: Implications for posttransplant outcomes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018
Same author

Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis.

Alimentary pharmacology & therapeutics·2016
Same author

Predonation Prescription Opioid Use: A Novel Risk Factor for Readmission After Living Kidney Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

The Changing Financial Landscape of Renal Transplant Practice: A National Cohort Analysis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Variation in Comedication Use According to Kidney Transplant Immunosuppressive Regimens: Application of Integrated Registry and Pharmacy Claims Data.

Transplantation proceedings·2016
Same author

Pneumococcal 13-Valent Conjugate Vaccine (Prevnar 13)-Associated Immune Thrombocytopenic Purpura in a Renal Transplant Recipient: A Case Report.

Transplantation proceedings·2016
Same journal

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Comment on "Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo & Uganda.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

OPERATIONAL TOLERANCE FOLLOWING INTESTINAL TRANSPLANTATION: A CASE REPORT WITH COMPREHENSIVE IMMUNE FOLLOW-UP FROM TRANSPLANT DAY TO THREE YEARS POST-IMMUNOSUPPRESSION WITHDRAWAL.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
See all related articles

Related Experiment Videos

Delayed graft function in the kidney transplant.

A Siedlecki1, W Irish, D C Brennan

  • 1Nephrology Division, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. andrew.siedlecki@gmail.com

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

Delayed graft function (DGF) after kidney transplantation is a common problem that harms long-term transplant success. Addressing donor and recipient factors is key to preventing DGF and improving patient outcomes.

Related Experiment Videos

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Surgical Pathology

Background:

  • Acute kidney injury frequently leads to delayed graft function (DGF) post-kidney transplantation.
  • Poor early graft function negatively impacts long-term allograft survival.
  • Increasing demand for renal allografts includes high-risk organs from deceased donors, exacerbating DGF concerns.

Purpose of the Study:

  • To explore the multifactorial causes of DGF in kidney transplantation.
  • To highlight the challenges in understanding and mitigating DGF.
  • To discuss emerging therapeutic strategies targeting inflammation in high-risk grafts.

Main Methods:

  • Review of pathological contributors from donor (ischemia, inflammation) and recipient (reperfusion, immune responses).
  • Analysis of challenges posed by new organ categories in deceased donor transplantation.
  • Examination of current and future therapeutic approaches to manage DGF.

Main Results:

  • DGF is influenced by a complex interplay of donor-derived and recipient-derived factors.
  • High-risk donor organs present significant challenges for transplantation success.
  • Therapeutic interventions are being developed to manage inflammatory responses and mitigate DGF.

Conclusions:

  • Preventing DGF requires a comprehensive approach addressing injury throughout the transplantation process.
  • Anticipating and treating tissue injury is crucial for improving long-term kidney allograft outcomes.
  • Future success in reducing DGF hinges on coordinated efforts in managing donor and recipient factors.