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Updated: May 29, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Bidirectional relation between schizophrenia and epilepsy: a population-based retrospective cohort study.

Yu-Tzu Chang¹, Pei-Chun Chen, I-Ju Tsai

¹Division of Pediatric Neurology, Department of Pediatrics, China Medical University and Hospital, Taichung, Taiwan.

|September 21, 2011

Summary

Schizophrenia and epilepsy show a strong two-way link, with each disorder increasing the risk of developing the other. These conditions may share underlying causes, warranting further investigation into their connection.

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

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Published on: November 13, 2016

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

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Published on: November 1, 2019

Area of Science:

Neuroscience
Psychiatry
Epidemiology

Background:

Schizophrenia and epilepsy are distinct neurological and psychiatric disorders.
Previous research suggests a potential shared susceptibility between schizophrenia and epilepsy.
Understanding this relationship is crucial for improving patient care and developing targeted interventions.

Purpose of the Study:

To investigate the bidirectional relationship between schizophrenia and epilepsy.
To determine if schizophrenia increases the risk of developing epilepsy.
To assess if epilepsy increases the risk of developing schizophrenia.

Main Methods:

Retrospective cohort analyses using Taiwan's National Health Insurance database.
Analysis 1: Compared 5,195 schizophrenia patients with 20,776 matched controls for epilepsy incidence.
Analysis 2: Compared 11,527 epilepsy patients with 46,032 matched controls for schizophrenia incidence.

Main Results:

Schizophrenia patients had a 5.88-fold increased risk of developing epilepsy.
Epilepsy patients had a 7.65-fold increased risk of developing schizophrenia.
The association was stronger in women for schizophrenia-to-epilepsy and in men for epilepsy-to-schizophrenia.

Conclusions:

A significant bidirectional relationship exists between schizophrenia and epilepsy.
The findings suggest shared underlying causes for both disorders.
Further research is needed to elucidate the specific mechanisms driving this association.