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Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
Published on: November 10, 2015
Genetic polymorphisms linked to susceptibility to malaria.
Adel Driss1, Jacqueline M Hibbert, Nana O Wilson
1Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA. adel@weboris.com
Malaria Journal
|September 21, 2011
Summary
Host genetics significantly influence malaria susceptibility, with Plasmodium falciparum driving human genome evolution. Research identifies genetic markers for malaria resistance and severity, aiding intervention development.
Area of Science:
- Genetics
- Immunology
- Infectious Diseases
Background:
- Host genetics play a crucial role in Plasmodium falciparum malaria susceptibility.
- Malaria parasites exert strong selective pressures on the human genome in endemic areas.
- Understanding genetic factors is key to addressing malaria's diverse clinical manifestations.
Purpose of the Study:
- To review and discuss human gene polymorphisms associated with susceptibility or resistance to P. falciparum malaria.
- To highlight advances in human genome research technologies for identifying malaria-related genetic markers.
- To explore the impact of genetic diversity and environmental factors on malaria's clinical heterogeneity.
Main Methods:
- Review of scientific literature on host genetics and malaria.
- Analysis of findings from genome-wide association studies (GWAS) and fine genotyping.
- Discussion of identified genetic polymorphisms and their association with malaria phenotypes.
Main Results:
- Numerous gene polymorphisms linked to malaria susceptibility and resistance have been identified.
- Factors like parasitemia, inflammation, anemia, and erythrocyte sequestration contribute to malaria severity.
- Some genetic findings are inconclusive or contradictory, requiring cautious interpretation.
Conclusions:
- Genetic markers for malaria phenotypes are vital for understanding malaria pathophysiology and developing interventions.
- Further investigation into human genetic diversity and environmental influences is necessary for improved malaria management.
- Identifying host genetic factors can lead to novel therapies and better control strategies against malaria.
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