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10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Colorectal anomalies in patients with classic bladder exstrophy
Andrew A Stec1, Nima Baradaran, Christine Tran
1Division of Pediatric Urology, The Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. andrew.stec@jhmi.edu
Journal of Pediatric Surgery
|September 21, 2011
Summary
Children with classic bladder exstrophy (CBE) have a 1.8% rate of colorectal anomalies, primarily imperforate anus. Early evaluation and treatment are crucial for managing these significant associated conditions.
Area of Science:
- Pediatric Surgery
- Congenital Anomalies
- Urology
Background:
- Classic bladder exstrophy (CBE) is a complex congenital condition affecting the genitourinary system.
- Associated gastrointestinal malformations in CBE patients are not well-characterized.
- Understanding these comorbidities is vital for comprehensive patient care.
Purpose of the Study:
- To determine the incidence and types of colorectal anomalies in children with CBE.
- To assess the significance of these anomalies in the context of CBE.
Main Methods:
- Retrospective review of a database of 1044 patients with bladder exstrophy-epispadias-cloacal exstrophy complex.
- Detailed medical record review for 676 patients diagnosed with CBE.
- Identification and extraction of history for patients with gastrointestinal malformations.
Main Results:
- 12 out of 676 patients with CBE (1.8%) had a concomitant colorectal anomaly.
- Imperforate anus was the most common anomaly (8 patients).
- Other anomalies included severe rectal stenosis (2 patients) and congenital rectal prolapse (2 patients).
Conclusions:
- Isolated colorectal anomalies occur in 1.8% of children with CBE, a 72-fold increase over the general population.
- Despite being uncommon, these anomalies carry significant morbidity.
- Prompt evaluation and treatment of both genitourinary and colorectal issues are essential.
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