Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-dose radiation effects: interactions and synergism.

J B Little1

  • 1Laboratory of Radiobiology, Harvard University School of Public Health, Boston, MA 02115.

Health Physics
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Cell death and differentiation·2014
Same author

[Nontargeted effects of ionizing radiation: implications for low-dose exposures].

Radiatsionnaia biologiia, radioecologiia·2007
Same author

Regulation of normal cell cycle progression by flavin-containing oxidases.

Oncogene·2007
Same author

Levels of gamma-H2AX Foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two at families and in another apparently normal individual.

Radiation research·2006
Same author

gamma-H2AX foci after low-dose-rate irradiation reveal atm haploinsufficiency in mice.

Radiation research·2006
Same author

Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations.

Radiation research·2005

Low doses of ionizing radiation can cause mutations and cancer, and chemicals can alter these effects. Experimental studies offer insights into radiation risks and reduction strategies, surpassing human epidemiology.

Area of Science:

  • Radiation biology
  • Chemical mutagenesis
  • Carcinogenesis

Background:

  • Experimental data demonstrate mutagenic and carcinogenic effects of low-dose ionizing radiation.
  • Chemical agents can modify these radiation-induced effects.
  • Studies include in vitro mutagenesis, neoplastic transformation, and in vivo lung cancer induction in hamsters.

Purpose of the Study:

  • To discuss experimental findings on ionizing radiation's mutagenic and carcinogenic effects.
  • To explore the modification of these effects by chemical agents.
  • To suggest future research directions for understanding radiation risks.

Main Methods:

  • In vitro studies of mutagenesis and neoplastic transformation.
  • In vivo induction of lung cancer in hamsters.

Related Experiment Videos

  • Analysis of experimental data on low dose and low dose-rate radiation exposure.

    • Main Results:

    • Low dose and low dose-rate ionizing radiation exposure exhibit mutagenic and carcinogenic potential.
    • Chemical agents can modulate the mutagenic and carcinogenic effects of radiation.
    • Experimental systems provide valuable data for risk assessment.

    Conclusions:

    • Future research should focus on human cell systems for radiation mutagenesis and transformation studies.
    • Investigating the effects of protracted radiation exposure in human cells is crucial.
    • Further examination of secondary factors in radiation carcinogenesis is needed.
    • Experimental systems are key to understanding radiation risks and mitigation strategies.