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Related Experiment Video

Updated: May 29, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Metabolomics and bladder cancer.

Matthew E Hyndman1, Jeffrey K Mullins, Trinity J Bivalacqua

  • 1James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. mhyndma1@jhmi.edu

Urologic Oncology
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

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Noninvasive urine tests using metabolomics show promise for diagnosing bladder cancer. This approach, analyzing metabolites with HPLC and NMR, could offer a new diagnostic standard beyond current methods.

Area of Science:

  • Urology
  • Analytical Chemistry
  • Biochemistry

Background:

  • Bladder cancer diagnosis relies on cystoscopy and urine cytology, the current gold standards.
  • Significant investment has been made in developing noninvasive urinary assays for urothelial carcinoma.
  • Existing methods have limitations, driving the search for improved diagnostic tools.

Purpose of the Study:

  • To review published studies on the use of metabolomics for bladder cancer diagnosis.
  • To explore the potential of urine-based metabolomics as a noninvasive diagnostic method.
  • To assess the current state and future prospects of metabolomic analysis in urothelial carcinoma detection.

Main Methods:

  • Review of scientific literature focusing on metabolomics and bladder cancer.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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Last Updated: May 29, 2026

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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  • Analysis of studies employing high-pressure liquid chromatography (HPLC) for metabolite separation.
  • Examination of studies utilizing nuclear magnetic resonance (NMR) spectroscopy for metabolite identification.

    • Main Results:

    • Proof-of-principle studies suggest metabolomics can accurately diagnose bladder cancer noninvasively.
    • Metabolomic profiling of urine shows potential for differentiating cancer patients from healthy individuals.
    • HPLC and NMR are key technologies enabling these promising diagnostic findings.

    Conclusions:

    • Urine-based metabolomics represents a developing field with significant potential for bladder cancer diagnosis.
    • This noninvasive approach may complement or eventually offer an alternative to cystoscopy.
    • Further research is warranted to validate and implement metabolomic assays in clinical practice.