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Synthesis and structure determination of FR109615, a new antifungal antibiotic
K Kawabata1, Y Inamoto, K Sakane
1New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
The Journal of Antibiotics
|May 1, 1990
Abstract:
The structure of FR109615, a new antifungal antibiotic, was determined to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid ((-)-cis-2-ACPC: 8a) by X-ray analysis. (-)-cis-2-ACPC (8a) was also synthesized via optical resolution of 3a and 3b derived from (+/-)-cis-2-ACPC hydrochloride (1). 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity.