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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Updated: May 29, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

HCVpro: hepatitis C virus protein interaction database.

Samuel K Kwofie1, Ulf Schaefer, Vijayaraghava S Sundararajan

  • 1South African National Bioinformatics Institute, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville 7535, Cape Town, South Africa. samuel@sanbi.ac.za

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

Cataloging hepatitis C virus (HCV) protein-protein interactions (PPIs) aids therapy development. The HCVpro database integrates HCV-virus and virus-human PPI data, functional genomics, and HCC-related genes for research.

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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Area of Science:

  • Virology
  • Bioinformatics
  • Molecular Biology

Background:

  • Characterized hepatitis C virus (HCV) protein-protein interaction (PPI) data and functional information are crucial for developing therapies, vaccines, and diagnostic biomarkers.
  • Existing resources often lack comprehensive integration of HCV-specific PPIs and related molecular data.

Purpose of the Study:

  • To develop and present the hepatitis C virus protein interaction database (HCVpro), a centralized knowledgebase for HCV-related protein interactions and functional data.
  • To facilitate research into HCV pathogenesis and therapeutic strategies by consolidating diverse biological information.

Main Methods:

  • Integrated manually verified HCV-virus and virus-human PPI data curated from literature and databases.
  • Consolidated information from virus-specific databases (VirHostNet, VirusMint, HCVdb, euHCVdb) and general repositories (BIND).
  • Mapped proteins to Gene Ontologies, canonical pathways, OMIM, and cross-referenced annotations; included HCC-related genes and reviews.

Main Results:

  • Developed HCVpro, a comprehensive HCV-specific knowledgebase detailing PPIs, functional genomics, and molecular data.
  • Enriched the database with information on hepatocellular carcinoma (HCC) related genes, pathway analysis, and extensive cross-references.
  • Provided user-friendly querying capabilities based on protein IDs, chromosomal locations, interaction methods, and database identifiers.

Conclusions:

  • HCVpro serves as a valuable, integrated resource for researchers studying hepatitis C virus.
  • The database supports the discovery of novel therapeutic targets, diagnostic biomarkers, and vaccine candidates for HCV infection.
  • HCVpro is freely accessible, promoting wider scientific collaboration and advancement in HCV research.