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Updated: May 29, 2026
Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
Published on: August 21, 2021
DNA repair systems in malignant mesothelioma
Dimitrios Toumpanakis1, Stamatios E Theocharis
1Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, Goudi, Athens, Greece.
Abstract:
Malignant mesothelioma (MM) is an aggressive tumor of serosal surfaces with increasing incidence and poor prognosis. Asbestos exposure is the main cause of MM and asbestos-induced DNA damage is critical for MM pathogenesis. The present review summarizes the implications of DNA repair systems in MM development, focusing on gene expression alterations and single nucleotide polymorphisms of genes encoding for DNA repair enzymes. The involvement of DNA repair systems in MM improves understanding of MM pathogenesis and provides novel therapeutical targets.
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