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Related Experiment Video

Updated: May 29, 2026

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
05:04

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Published on: November 19, 2020

Left main stenting: is it a different animal?

Seung-Jung Park1, Duk-Woo Park

  • 1Division of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, Korea. sjpark@amc.seoul.kr

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|September 21, 2011
PubMed
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Percutaneous coronary intervention (PCI) with stenting and coronary-artery bypass grafting (CABG) show similar outcomes for unprotected left main coronary artery (LMCA) disease. Repeat revascularization rates differ, with PCI requiring more frequent procedures.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Surgery

Background:

  • Coronary-artery bypass grafting (CABG) has historically been the primary treatment for unprotected left main coronary artery (LMCA) disease.
  • Advancements in percutaneous coronary intervention (PCI) with stenting and CABG necessitate a re-evaluation of optimal revascularization strategies for LMCA disease.

Purpose of the Study:

  • To review and evaluate current indications for optimal revascularization therapy in patients with unprotected LMCA disease.
  • To determine the current standard of care for LMCA disease considering recent therapeutic advancements.

Main Methods:

  • Comparative analysis of existing evidence comparing PCI with stenting versus CABG for LMCA disease.
  • Review of outcomes including death, myocardial infarction, stroke, and repeat revascularization.

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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Related Experiment Videos

Last Updated: May 29, 2026

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
05:04

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Published on: November 19, 2020

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

  • Assessment of technical challenges and outcomes in specific high-risk anatomic subsets, particularly distal LMCA bifurcation lesions.

    • Main Results:

    • The composite outcome of death, myocardial infarction, and stroke is comparable between PCI with stenting and CABG for LMCA disease.
    • A significant difference was observed in the rate of repeat revascularization, with PCI requiring more frequent procedures.
    • PCI is technically feasible for most LMCA lesions, but distal bifurcation lesions pose significant challenges.

    Conclusions:

    • Current evidence suggests similar overall clinical outcomes for PCI and CABG in LMCA disease, with repeat revascularization being a key differentiator.
    • An integrated approach combining advanced devices, tailored techniques, physiologic/morphologic evaluation, and pharmacologic agents is crucial for improving outcomes in complex LMCA PCI.
    • Further research and clinical evaluation are needed to refine the standard of care for LMCA disease management.