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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Updated: May 29, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Review on methicillin-resistant Staphylococcus pseudintermedius.

Engeline van Duijkeren1, Boudewijn Catry, Christina Greko

  • 1Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands. e.vanduijkeren@uu.nl

The Journal of Antimicrobial Chemotherapy
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a growing threat in dogs. This review covers MRSP

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Area of Science:

  • Veterinary Microbiology
  • Infectious Diseases
  • Companion Animal Health

Background:

  • Staphylococcus pseudintermedius is a common opportunistic pathogen in dogs.
  • Methicillin-resistant S. pseudintermedius (MRSP) has emerged significantly since 2006, primarily through clonal spread.
  • MRSP poses a threat to companion animal health.

Purpose of the Study:

  • To review current research on MRSP.
  • To focus on MRSP occurrence, identification, risk factors, zoonotic potential, and control.
  • To identify future research directions for MRSP.

Main Methods:

  • Literature review of scientific research on MRSP.
  • Analysis of studies on MRSP epidemiology and diagnostics.
  • Synthesis of information on MRSP risk factors, zoonotic potential, and control strategies.

Main Results:

  • MRSP emergence is linked to clonal spread.
  • Various methods exist for MRSP identification.
  • Risk factors for colonization and infection are identified.
  • Zoonotic potential and control options are discussed.

Conclusions:

  • MRSP is an important emerging pathogen in companion animals.
  • Further research is needed to address knowledge gaps in MRSP control and prevention.
  • Understanding MRSP is crucial for veterinary medicine and public health.