Multiple lesions of granuloma annulare on the hand in a patient with scabies

Khalid Al Aboud1, Daifullah Al Aboud

  • 1Department of Dermatology, King Faisal Hospital, Makkah.

Insights

Scabies infection can trigger granuloma annulare, a rare skin condition. This report details a fourth documented case of this association, highlighting a potential link between the two conditions.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pathology

Background:

  • Granuloma annulare is a benign inflammatory skin condition characterized by annular lesions.
  • Scabies is a contagious skin infestation caused by the mite Sarcoptes scabiei.
  • Previous literature has documented a rare association between scabies infection and granuloma annulare.

Observation:

  • This report presents the fourth documented case of granuloma annulare developing subsequent to scabies infection.
  • The patient presented with clinical and histopathological features consistent with granuloma annulare following a confirmed scabies infestation.

Findings:

  • The findings support a potential causal or triggering role of scabies infection in the development of granuloma annulare in susceptible individuals.
  • Histopathological examination confirmed granuloma annulare, distinct from typical scabies-related inflammatory responses.

Implications:

  • This case adds to the limited evidence suggesting that scabies may act as an uncommon trigger for granuloma annulare.
  • Further research is warranted to elucidate the immunopathological mechanisms underlying this association.
  • Dermatologists should consider scabies as a potential precipitating factor in patients presenting with granuloma annulare, particularly in endemic areas.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...