Related Experiment Video
Updated: May 5, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection
George Nicholson1, Mattias Rantalainen, Jia V Li
1Department of Statistics, University of Oxford, Oxford, United Kingdom. nicholso@stats.ox.ac.uk
Abstract:
We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10(-11)
Related Concept Videos
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Incomplete Dominance
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets
Modern Molecular Taxonomy
Evolution of New Traits in Microbes

