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Related Concept Videos

Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Precocious puberty and a sellar mass.

Anil Bhansali1, P Jayaprakash, Pinaki Dutta

  • 1Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

BMJ Case Reports
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

A rare case of precocious puberty in a young child was successfully treated with levothyroxine. This treatment resolved both the early development of secondary sexual characteristics and a sellar mass.

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Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology
  • Pediatric Neurosurgery

Background:

  • Precocious puberty in children under 3 typically involves gonadotropin dependence and central nervous system issues.
  • Gonadotropin-independent precocious puberty is less common and can be associated with sellar masses.

Purpose of the Study:

  • To report a unique case of gonadotropin-independent precocious puberty in a 2½-year-old girl.
  • To highlight the association between autoimmune primary hypothyroidism, precocious puberty, and a sellar mass.

Main Methods:

  • Case report of a 2½-year-old girl with precocious puberty and a sellar mass.
  • Diagnostic workup including hormonal evaluation and imaging.
  • Treatment with levothyroxine for primary hypothyroidism.

Main Results:

  • The patient presented with gonadotropin-independent precocious puberty and a sellar mass.
  • Investigations revealed autoimmune primary hypothyroidism with thyrotroph hyperplasia.
  • Treatment with levothyroxine led to regression of secondary sexual characteristics and disappearance of the sellar mass.

Conclusions:

  • Autoimmune primary hypothyroidism can rarely cause gonadotropin-independent precocious puberty and a sellar mass due to thyrotroph hyperplasia.
  • Levothyroxine therapy is an effective treatment for this specific condition.
  • This case underscores the importance of considering endocrine etiologies for sellar masses in children.