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Related Experiment Video

Updated: May 29, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Modulation of human time processing by subthalamic deep brain stimulation.

Lars Wojtecki1, Saskia Elben, Lars Timmermann

  • 1Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany. wojtecki@uni-duesseldorf.de

Plos One
|September 21, 2011
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) for Parkinson's disease (PD) affects interval timing. Low-frequency (10 Hz) subthalamic nucleus (STN) DBS specifically worsened 15-second interval timing, unlike high-frequency stimulation.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Interval timing, crucial for cognition, involves basal ganglia (BG) oscillatory loops.
  • Parkinson's disease (PD), a BG disorder, impairs interval timing.
  • Subthalamic nucleus deep brain stimulation (STN-DBS) modulates BG functions.

Purpose of the Study:

  • To investigate if STN-DBS frequency influences interval timing in PD patients.
  • To understand the role of BG and STN in time perception.

Main Methods:

  • A randomized, within-subject, double-blind study comparing no stimulation, 10 Hz, and ≥130 Hz STN-DBS in 12 PD patients.
  • Assessment of 5-second and 15-second interval production/reproduction and millisecond timing against healthy controls.

Main Results:

  • PD patients showed underproduction of 15-second intervals.
  • 10 Hz STN-DBS significantly worsened this underproduction compared to no stimulation, high-frequency DBS, and controls.
  • Millisecond timing remained unaffected by STN-DBS.

Conclusions:

  • First evidence for frequency-specific modulation of interval timing by STN-DBS.
  • Results support the involvement of BG, particularly the STN, in processing multi-second time intervals.