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Two additional cases of t dic(9:12) in acute lymphocytic leukemia (ALL): prognosis in ALL with dic(9:12)
J L Huret1, N A Heerema, A Brizard
1Département d'Hématologie et Oncologie Médicale, CNRS URA 1338, Hôpital Jean Bernard, Poitiers, France.
Abstract:
We report two occurrences of dic(9;12) in acute lymphoblastic leukemia and review previous cases. Cases of dic(9;12) share common features with cases of 9p and 12p rearrangements, but prognosis seems particularly good in cases of dic(9;12). The persistence of a specific dicentric in stable clones is remarkable and points to unusual centromeric behavior and/or marked selective advantage of the anomaly.
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