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Cardioplegia and ventricular late potentials in cardiac surgical patients

N Schütz1, J-A Romand, N D Yanez

  • 1Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.

Journal of Clinical Monitoring and Computing
|September 21, 2011
PubMed

Insights

Cardiac surgery with cardiopulmonary bypass (CPB) and cardioplegia do not significantly impact ventricular late potentials (LP) in patients without prior heart attacks. This study found no increased risk of arrhythmias after such procedures.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Ventricular late potentials (LP) on signal-averaged electrocardiograms (SAECG) identify patients at risk for sudden cardiac death and ventricular tachycardia.
  • Cardiac surgery using cardiopulmonary bypass (CPB) may induce myocardial ischemia, potentially affecting LP.
  • No prior studies have examined the effect of cardioplegia and CPB on LP in patients without a history of myocardial infarction undergoing cardiac surgery.

Purpose of the Study:

  • To investigate the impact of cardioplegia and CPB on the occurrence of ventricular late potentials (LP) in patients without previous myocardial infarction undergoing cardiac surgery.

Main Methods:

  • Signal-averaged electrocardiograms (SAECG) were recorded in 61 elective cardiac surgery patients before and 24-48 hours after CPB.
  • Thirty-six patients with adequate signal quality were analyzed.
  • McNemar's tests were used to compare pre- and post-operative LP scores.

Main Results:

  • No significant difference was observed in LP occurrence before and after CPB (P = NS).
  • The mean CPB duration was 110 ± 57 minutes.
  • The probability of transitioning from a negative to a positive LP score was 0.23 (P = NS).

Conclusions:

  • Cardioplegia combined with CPB does not appear to significantly affect the incidence of ventricular late potentials in cardiac surgical patients.
  • These findings suggest that the procedure itself, under these conditions, does not increase the risk of developing LP.
Abstract

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