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Updated: May 29, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Molecular imaging with SERS-active nanoparticles.

Yin Zhang¹, Hao Hong, Duane V Myklejord

¹Department of Medical Physics, University of Wisconsin-Madison, Room 7137, 1111 Highland Ave, Madison, WI 53705-2275, USA.

Small (Weinheim an Der Bergstrasse, Germany)

|September 21, 2011

Summary

This summary is machine-generated.

Surface-enhanced Raman scattering (SERS)-active nanoparticles offer powerful multiplexing for molecular imaging. This technique advances biomedical research by enabling simultaneous interrogation of multiple biological events, showing significant progress in recent years.

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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Published on: December 9, 2010

Area of Science:

Biomedical optics
Molecular imaging
Chemical sensing

Background:

Raman spectroscopy provides detailed chemical information of cells and tissues.
Enhanced sensitivity is crucial for Raman spectroscopy in imaging applications.
Surface-enhanced Raman scattering (SERS)-active nanoparticles have emerged as key tools for molecular imaging.

Purpose of the Study:

To review the advancements in SERS-based molecular imaging.
To highlight the potential of SERS nanoparticles in biomedical research.
To discuss the future prospects of SERS imaging.

Main Methods:

Utilizing SERS-active nanoparticles for enhanced Raman signal detection.
Developing multiplexing strategies for simultaneous detection of multiple targets.
Demonstrating proof-of-principle experiments in various biological systems.

Main Results:

SERS nanoparticles enable detailed chemical composition analysis of cells and tissues.
Successful demonstration of SERS-based Raman imaging in live animals.
Significant advancements in molecular imaging using SERS nanoparticles.

Conclusions:

SERS-based molecular imaging offers superb multiplexing capabilities.
The technique is powerful for simultaneous interrogation of multiple biological events.
SERS imaging is a dynamic and rapidly advancing research field with significant future potential.