Synthesis and anticancer activity of Indolin-2-one derivatives bearing the 4-thiazolidinone moiety
Shuobing Wang1, Yanfang Zhao, Wufu Zhu
1Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenhe District, Shenyang, P. R. China.
Abstract:
A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI-38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT-29 and H460 cancer cell lines (IC(50) = 0.016 µmol/L, 0.0037 µmol/L, respectively).
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