Related Experiment Video
Updated: May 29, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Longitudinal lung function declines among California flavoring manufacturing workers.
Kathleen Kreiss1, Kathleen B Fedan, Muazzam Nasrullah
1Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA. kkreiss@cdc.gov
Spirometric surveillance identified workers with abnormal lung function decline, even with normal FEV(1) levels. This method aids in preventing work-related respiratory issues in flavoring industry employees.
Area of Science:
- Occupational Health
- Pulmonary Medicine
- Industrial Hygiene
Background:
- Flavoring manufacturing workers face risks of bronchiolitis obliterans.
- Serial spirometry data were collected from 20 companies.
Purpose of the Study:
- To assess spirometry quality and identify workers with abnormal lung function decline.
- To analyze lung function decline in relation to occupational risk factors.
Main Methods:
- Spirometry quality was graded.
- Individual workers with excessive forced expiratory volume in 1 second (FEV(1)) decline were identified using relative longitudinal limits.
- Declines were analyzed by occupational risk factors.
Main Results:
- Poorer spirometry quality was noted from commercial providers.
- 9.6% of workers with at least two tests showed abnormal FEV(1) decline.
- Abnormal FEV(1) decline rates were higher in workers exposed to diacetyl and in companies with existing clusters of spirometric obstruction.
Conclusions:
- Spirometric surveillance can identify workers needing intervention for abnormal FEV(1) decline, even with normal FEV(1) values.
- High-quality spirometry and appropriate decline classification minimize misclassification of work-related health effects.
Related Concept Videos
Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Lung Capacity
Longitudinal Research
Chronic Obstructive Pulmonary Disease II: Emphysema
Respiratory Capacities
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...

