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Updated: May 29, 2026
05:45
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Summary
Hirschsprung's disease, a congenital condition affecting the large intestine, impacts both children and adults. This review covers its definition, prevalence, causes, classification, clinical features, diagnosis, and modern treatments.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Genetics
Context:
- Hirschsprung's disease is a congenital disorder characterized by the absence of ganglion cells in the distal bowel.
- It affects both pediatric and adult populations, presenting diverse clinical scenarios.
- Understanding its etiology, pathogenesis, and classification is crucial for effective management.
Purpose:
- To provide an updated overview of Hirschsprung's disease.
- To discuss current understanding of its definition, prevalence, and terminology.
- To evaluate diagnostic tools and treatment modalities.
Summary:
- This review details Hirschsprung's disease, including its definition, prevalence, and terminology debates.
- It examines etiology, pathogenesis, hereditary factors, and clinico-anatomic classification.
- Clinical variants, complications, diagnostic approaches, and treatment options are discussed.
Impact:
- Offers comprehensive insights into Hirschsprung's disease for clinicians and researchers.
- Highlights current knowledge gaps and areas of ongoing debate.
- Informs clinical decision-making and future research directions in pediatric and adult gastroenterology and surgery.
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