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Updated: May 29, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Abstract:
Up-to-date information about Hirschsprung's disease in children and adults is presented including definition of this pathology, data on its prevalence, and debatable questions of terminology. Etiology and pathogenesis of Hirschsprung"s disease, the role of hereditary factors in its development and clinico-anatomic classification are considered. Clinical variants of Hirschsprung's disease in children and adults are discussed along with its complications and combinations with other congenital malformations. Diagnostic and informative value of clinical and instrumental tools is assessed. Modern methods of conservative and surgical treatment are described.
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