Related Experiment Video
Updated: May 29, 2026
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Cord blood adiponectin and infant growth at one year
Shali Mazaki-Tovi1, Hannah Kanety, Clara Pariente
1Department of Obstetrics and Gynecology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
Insights
Cord blood adiponectin and leptin levels were lower in small for gestational age (SGA) infants. Lower adiponectin in SGA and appropriate for gestational age (AGA) infants correlated with reduced growth at one year.
Area of Science:
- Endocrinology
- Neonatal research
- Pediatric growth studies
Background:
- Adipokines, such as adiponectin and leptin, are crucial hormones regulating metabolism and growth.
- Infant growth patterns are influenced by various factors, including fetal development and early-life nutrition.
- Small for gestational age (SGA) infants often experience altered growth trajectories compared to appropriate for gestational age (AGA) infants.
Purpose of the Study:
- To investigate the relationship between cord blood adiponectin and leptin levels and infant growth up to one year of age.
- To compare these associations in both SGA and AGA newborns.
- To understand the potential role of adipokines in fetal programming of growth.
Main Methods:
- Prospective study design involving measurement of cord blood adiponectin and leptin.
- Inclusion of two groups: AGA newborns (n=44) and SGA newborns (n=24).
- Anthropometric measurements (height, weight, BMI) were taken at one year, with linear regression analysis applied.
Main Results:
- SGA neonates exhibited significantly lower median cord blood adiponectin and leptin levels compared to AGA neonates.
- In SGA infants, lower cord blood adiponectin correlated negatively with one-year body weight, weight gain, and BMI.
- Similarly, in AGA infants, lower cord blood adiponectin correlated negatively with one-year body weight, weight gain, and BMI.
Conclusions:
- The observed differences in cord blood adipokine concentrations between SGA and AGA neonates indicate a potential role for these hormones in fetal growth regulation.
- Adiponectin may influence postnatal growth trajectories in both SGA and AGA infants.
- These findings highlight the importance of adipokines in early development and growth outcomes.
Objective:
The aim of this study was to determine the association between cord blood adiponectin and leptin and early infant growth at one year in small for gestational age (SGA) and appropriate for gestational age (AGA) infants.
Study Design:
In this prospective study adiponectin and leptin concentrations were determined in cord blood of (i) AGA newborns (n = 44) and (ii) SGA newborns (n = 24). At one year of age, height and weight were measured. Linear regression analysis was used to determine which factors were associated with anthropometric measurements at the age of one year.
Results:
(i) SGA neonates had a significantly lower median cord blood adiponectin and leptin than AGA neonates; (ii) among SGA neonates, cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year; and (iii) among AGA neonates cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year.
Conclusion:
The disparity in cord blood adiponectin and leptin concentrations between SGA and AGA neonates suggests a role for adipokines in fetal growth.
