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Updated: May 29, 2026
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
An update on peripartum cardiomyopathy.
Jonathan R Dalzell1, Colette E Jackson, Roy S Gardner
1Scottish Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, UK. j.dalzell@nhs.net
Expert Review of Cardiovascular Therapy
|September 22, 2011
Summary
Peripartum cardiomyopathy (PPCM) is a rare pregnancy complication. Recent research suggests prolactin antagonism may treat PPCM, highlighting the need for increased clinical awareness and research.
Area of Science:
- Cardiology
- Obstetrics
- Reproductive Medicine
Background:
- Peripartum cardiomyopathy (PPCM) is a rare, severe pregnancy complication.
- Recent definition revisions exist, but pathogenesis, incidence, and prevalence remain poorly understood.
- PPCM is often under-recognized, necessitating increased clinical awareness.
Purpose of the Study:
- To review current literature on peripartum cardiomyopathy.
- To highlight recent advances in understanding PPCM pathogenesis and management.
- To emphasize the potential role of prolactin antagonism.
Main Methods:
- Literature review of peripartum cardiomyopathy.
- Analysis of recent studies on PPCM pathogenesis.
- Examination of preclinical data on prolactin antagonism.
Main Results:
- The pathogenesis of PPCM is not well understood.
- Prolactin's role in PPCM development and progression is a recent discovery.
- Preclinical studies indicate potential benefits of prolactin antagonism.
Conclusions:
- Increased awareness and recognition of PPCM are crucial in clinical practice.
- Further research into PPCM pathogenesis is warranted.
- Prolactin antagonism presents a promising therapeutic avenue for PPCM.
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