Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Influence of Parents and Peers on Identity01:23

Influence of Parents and Peers on Identity

Adolescence is a pivotal period of identity formation, during which individuals begin to answer questions central to their sense of self, such as "Who am I?" and "Who do I hope to become?" Both parents and peers play critical roles in guiding adolescents through this complex developmental phase.
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth. This guiding role...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Relationship with Parents: Attachment01:28

Relationship with Parents: Attachment

Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRGT-denovo: accurate detection of <i>de novo</i> tandem repeat mutations.

bioRxiv : the preprint server for biology·2024
Same author

ORE identifies extreme expression effects enriched for rare variants.

Bioinformatics (Oxford, England)·2019
Same author

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.

Nature communications·2017
Same author

Xq27 FRAXA locus is a strong candidate for dyslexia: evidence from a genome-wide scan in French families.

Behavior genetics·2013
Same author

A Case of Severe Puerperal Septicaemia; Injection of Antistreptococcic Serum; Recovery.

British medical journal·2010
Same author

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

Nature·2010
Same journal

Genetic Spectrum of Non-PTPN11 Variants in Noonan Syndrome and Related RASopathies: Findings From a Russian Cohort.

Clinical genetics·2026
Same journal

Phenotypic Characterization of Five Children With PACS1-NDD: Longitudinal Insights Into Development, Behavior, and Brain.

Clinical genetics·2026
Same journal

A Second Report of a Missense Variant in AMMECR1 Causing Midface Hypoplasia, Hearing Impairment, Elliptocytosis, and Nephrocalcinosis: Case Report and Literature Review.

Clinical genetics·2026
Same journal

From Pathogenicity to Mechanism: A Variant Interpretation Framework for Monogenic Epilepsy.

Clinical genetics·2026
Same journal

Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility.

Clinical genetics·2026
Same journal

Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.

Clinical genetics·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Parent of origin effects.

A Guilmatre1, A J Sharp

  • 1Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

Clinical Genetics
|September 22, 2011
PubMed
Summary
This summary is machine-generated.

Genome-wide association studies often overlook parent-specific gene effects, like genomic imprinting, which can influence complex diseases. Considering diverse inheritance patterns can improve understanding of human traits and disease causes.

More Related Videos

Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice
04:20

Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice

Published on: July 12, 2024

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
07:56

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice
04:20

Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice

Published on: July 12, 2024

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
07:56

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

Area of Science:

  • Genetics
  • Genomics
  • Epigenetics

Background:

  • Genome-wide association studies (GWAS) struggle to explain the full heritability of complex diseases.
  • Current GWAS typically assume parental alleles are functionally identical, ignoring potential differences.

Purpose of the Study:

  • To review mechanisms of parent of origin and trans-generational effects.
  • To propose alternative inheritance models for studying complex disorders.

Main Methods:

  • Literature review of parent of origin effects.
  • Analysis of mechanisms underlying trans-generational inheritance in humans and model organisms.

Main Results:

  • Genomic imprinting is one example where parental alleles differ functionally.
  • Various other parent of origin and trans-generational effects are documented across species.
  • These phenomena may be widespread in the genome.

Conclusions:

  • Alternative inheritance models, beyond standard Mendelian genetics, are crucial.
  • Incorporating these models can enhance the understanding of human trait heritability.
  • This approach may significantly impact the study of complex diseases.