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Updated: May 29, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
New drugs for prostate cancer
Constantine Alifrangis1, Ciara O'Hanlon-Brown, Mark Tuthill
1Department of Surgery and Cancer, Imperial College London, London, UK.
BJU International
|September 22, 2011
Summary
Recent clinical trials show promising new treatments for advanced prostate cancer, including therapies targeting hormone resistance and tumor immunology. These advances offer hope and exemplify mechanism-based drug discovery for metastatic disease.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Recent therapeutic research has yielded advancements in immunology, targeted biological therapy, and hormone-refractory disease management.
- The landscape of advanced prostate cancer treatment is rapidly evolving with novel therapeutic strategies.
Purpose of the Study:
- To review key late-stage clinical developments in new therapies for advanced prostate cancer.
- To contextualize these advances within patient management strategies for metastatic prostate cancer.
Main Methods:
- A comprehensive literature search of the PubMed database was conducted.
- Articles focused on prostate cancer therapeutics clinical trials published within the last three years were included.
Main Results:
- Key positive clinical trials were identified in androgen resistance, tumor immunology, molecularly targeted agents, and cytotoxic therapies.
- These findings were discussed in relation to their impact on metastatic prostate cancer management.
Conclusions:
- Emerging treatments from these research areas are advancing into clinical trials.
- These developments represent significant progress in mechanism-based drug discovery and offer hope for patients with advanced prostate cancer.
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