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Risk factors and prognosis of young stroke. The FUTURE study: a prospective cohort study. Study rationale and

Loes C A Rutten-Jacobs1, Noortje A M Maaijwee, Renate M Arntz

  • 1Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

BMC Neurology
|September 22, 2011
PubMed

Insights

The FUTURE study investigates risk factors and long-term outcomes for young stroke patients, offering crucial insights into prognosis and mortality for individuals with decades of life expectancy.

Area of Science:

  • Neurology
  • Epidemiology
  • Vascular Medicine

Background:

  • Young stroke significantly impacts quality of life, work, and social participation.
  • Limited data exists on risk factors and long-term prognosis for young stroke survivors.
  • Understanding long-term outcomes is vital given the extended life expectancy of this demographic.

Purpose of the Study:

  • To identify risk factors and determine the long-term prognosis of young ischemic and hemorrhagic stroke.
  • To assess the risk of mortality and recurrent vascular events in young stroke patients.
  • To enhance knowledge for physicians and patients regarding young stroke outcomes.

Main Methods:

  • Prospective cohort study (FUTURE study) of 1006 patients aged 18-50 years.
  • Data collected between 1980-2010, with follow-up visits from 2009-2011.
  • Includes ischemic and hemorrhagic stroke, healthy controls, questionnaires, and extensive MRI sub-studies.

Main Results:

  • Data on mortality and incident vascular events collected via questionnaires.
  • Extensive sub-study including MRI performed during follow-up visits.
  • Comparison with healthy controls for enhanced risk factor analysis.

Conclusions:

  • The FUTURE study offers a unique, long-term perspective (up to 30 years) on young stroke.
  • Inclusion of diverse stroke types (ischemic, hemorrhagic, TIA) and healthy controls strengthens findings.
  • Expected to provide valuable information for managing young stroke patients and improving their prognosis.
Abstract

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