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The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

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Post-stroke infection: a systematic review and meta-analysis.

Willeke F Westendorp¹, Paul J Nederkoorn, Jan-Dirk Vermeij

¹Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.

|September 22, 2011

Summary

Infections affect 30% of acute stroke patients, with pneumonia and urinary tract infections each occurring in 10%. Pneumonia significantly increases the risk of death, highlighting the need for infection prevention strategies in stroke care.

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Area of Science:

Neurology
Infectious Diseases
Public Health

Background:

Stroke is a leading cause of death and disability globally.
Patients with acute stroke are highly susceptible to infections.
Existing data on post-stroke infection rates show considerable variability.

Purpose of the Study:

To systematically review and meta-analyze studies on post-stroke infections.
To estimate the pooled incidence of infections following acute stroke.
To investigate the impact of infections on stroke patient outcomes.

Main Methods:

Comprehensive search of MEDLINE and EMBASE databases for relevant cohort studies and randomized clinical trials.
Pooled analysis of infection rates, assessing heterogeneity across studies.
Quantification of associations between population/study characteristics and infection rates.
Review of the relationship between post-stroke infections and patient outcomes.

Main Results:

Analysis of 87 studies involving 137,817 patients revealed a pooled infection rate of 30%.
Pneumonia and urinary tract infections were the most common, each with a 10% incidence rate.
Intensive care unit (ICU) patients exhibited higher infection rates (45%), with pneumonia at 28% and UTI at 20%.
Pneumonia was significantly associated with increased mortality (OR 3.62).

Conclusions:

Infections are a significant complication in acute stroke, affecting 30% of patients.
Pneumonia and urinary tract infections are prevalent post-stroke.
Pneumonia is a critical factor linked to mortality, underscoring the importance of infection prevention in stroke management.