Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis
Chao Cao1, Yan-mei Zhang, Ran Wang
1Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, Zhejiang 315020, China.
Chinese Medical Journal
|September 22, 2011
Summary
This meta-analysis found no significant association between ERCC1 gene polymorphisms (T1900C, C8092A) and lung cancer risk in Caucasian or Han Chinese populations. Further research is needed to clarify the role of these genetic variations in lung cancer development.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Conflicting results exist regarding the association between ERCC1 gene polymorphisms and lung cancer risk.
- Previous studies had relatively small sample sizes, necessitating a meta-analysis.
Purpose of the Study:
- To perform a meta-analysis evaluating the association between ERCC1 polymorphisms (T1900C and C8092A) and lung cancer risk.
- To aggregate evidence from multiple studies to provide a more robust conclusion.
Main Methods:
- Systematic review and meta-analysis of eligible studies.
- Searches conducted in Embase, Ovid, Medline, and Chinese National Knowledge Infrastructure.
- Data aggregated using statistical meta-analysis techniques.
Main Results:
- T19007C polymorphism showed no significant effect on lung cancer risk in pooled analyses or stratified analyses by ethnicity.
- C8092A polymorphism also showed no significant association with lung cancer risk.
- The study included 3810 lung cancer cases and 4332 controls for T19007C, and 3060 patients and 2729 controls for C8092A.
Conclusions:
- Little evidence supports an association between ERCC1 T1900C or C8092A polymorphisms and lung cancer risk.
- Findings apply to both Caucasian and Han Chinese populations.
- The role of these specific ERCC1 polymorphisms in lung cancer susceptibility remains unclear.
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