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Updated: May 29, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

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Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex

Sabine Gorynia1, Tiago M Bandeiras, Filipa G Pinho

  • 1Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.

Journal of Structural Biology
|September 22, 2011
PubMed
Summary

The RuvBL1 and RuvBL2 complex structure reveals a dodecameric ring, essential for DNA repair and cancer regulation. Domain II truncation enhances ATP consumption and DNA unwinding activity, suggesting cofactor-mediated regulation.

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