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Association of dyslipidaemia with cholilithiasis and effect of cholecystectomy on the same

Ajaz Ahmad Malik1, Mohd Lateef Wani, Shahid Iqbal Tak

  • 1Department of General Surgery, Cardiac Surgery, Cardiology, Radiology, Sher-i-Kashmir Institute of Medical Sciences Srinagar, J&K, India.

International Journal of Surgery (London, England)
|September 22, 2011
PubMed

Insights

Cholelithiasis (gallstones) is linked to abnormal lipid profiles. Cholecystectomy significantly reduces plasma lipids, potentially lowering coronary artery disease risk in patients.

Area of Science:

  • Cardiovascular Science
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Gallstones are associated with dyslipidemia and increased risk of cardiovascular events like stroke.
  • Understanding the link between gallstones and lipid abnormalities is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the association between dyslipidemia and cholelithiasis (gallstones).
  • To evaluate the impact of cholecystectomy on lipid profiles in patients with gallstones.

Main Methods:

  • Prospective study of 73 patients with symptomatic gallstones.
  • Analysis of plasma lipid concentrations (cholesterol, triglycerides, LDL, HDL) preoperatively and postoperatively.
  • No lipid-lowering drugs or dietary restrictions were imposed on participants.

Main Results:

  • Preoperative lipid abnormalities were prevalent in 80% of females and 71.42% of males.
  • Significant reductions in total cholesterol, triglycerides, and LDL cholesterol were observed on day 3 and 6 months post-cholecystectomy.
  • HDL cholesterol levels showed no significant change 6 months after surgery.

Conclusions:

  • Cholecystectomy leads to significant postoperative reductions in plasma lipid concentrations.
  • These lipid changes post-cholecystectomy may influence the development of coronary artery disease.
Abstract

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