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Pediatric solid malignant neoplasms: a comparative analysis
Bryan E Harmon1, Kenneth Friedman, Barbara Nemesure
1Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794-7025, USA.
Insights
Geographic variations in pediatric solid malignant neoplasms (PSMNs) were observed. This study highlights differences in tumor types and frequencies between the US and India, underscoring the need for global awareness of PSMNs.
Area of Science:
- Pediatric Oncology
- Epidemiology
- Cancer Research
Background:
- Pediatric solid malignant neoplasms (PSMNs) are a major cause of childhood mortality worldwide.
- Understanding the epidemiological patterns of PSMNs is crucial for targeted interventions and improved outcomes.
Purpose of the Study:
- To analyze the incidence and patterns of PSMNs at a US hospital.
- To compare these findings with data from India and global registries.
- To identify geographic variations in pediatric cancer types and frequencies.
Main Methods:
- Retrospective review of 127 PSMN cases at Stony Brook University Medical Center (2000-2008).
- Comparison with 101 PSMN cases from an Indian hospital (1975-1982) and global data.
- Statistical analysis, including Fisher's Exact test, to assess significant differences.
Main Results:
- The US cohort had a male to female ratio of 1.16:1 and a mean age of 4.8 years.
- Central nervous system (CNS) and sympathetic nervous system (SNS) tumors were more frequent in the US compared to global registries.
- The Indian cohort showed a higher male to female ratio (4:1) and different tumor category frequencies, with statistically significant differences in CNS tumors, lymphomas, and retinoblastomas.
Conclusions:
- Significant geographic variations exist in the incidence and histology of pediatric solid malignant neoplasms.
- Despite advances, PSMNs remain a critical and often fatal challenge in pediatric healthcare globally.
Background:
Pediatric solid malignant neoplasms (PSMNs) are a significant cause of death among children. Our aim was to evaluate the pattern and frequency of PSMNs at our hospital in the United States and compare the results to data from other regions of the world.
Materials And Methods:
This is a retrospective review of 127 PSMNs in the Pathology database at Stony Brook University Medical Center (SBUMC) from 2000 to 2008. We compared our cases to a cohort of 101 cases from an academic hospital in India (1975-1982) (Christian Medical College and Hospital) and to reports from other parts of the world.
Results:
We report a male to female ratio of 1.16 : 1 and a mean age of 4.8 years for cases at SBUMC. Lymphomas and central nervous system (CNS) neoplasms were more common in the 5-12-year-old group while other major diagnostic groups were more common in the 0-4-year-old group. The top five most frequent tumor categories included CNS, sympathetic nervous system (SNS), soft tissue, lymphoid and renal tumors. Lymphomas were more common than soft tissue and SNS tumors in the United States' registries but all three occurred with equal frequency in our study. Tumors of the soft tissue and SNS were more frequent at SBUMC compared to registries around the world. At the academic hospital in India, the male to female ratio was 4 : 1 and the five most frequent tumor categories included lymphoid, SNS, CNS, renal and bone tumors. Lymphoid tumors made up a greater percentage and CNS tumors made up a lesser percentage of tumors at the hospital in India compared with SBUMC. The differences between CNS tumors, lymphomas and retinoblastomas between the two hospitals were statistically significant (P value <0.05 by Fisher's Exact test).
Conclusions:
Geographic differences in the incidence and histologic types of PSMNs exist. Despite advancements in diagnosis and treatment, PSMNs continue to be tragically lethal.
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