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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Pediatric solid malignant neoplasms: a comparative analysis.

Bryan E Harmon1, Kenneth Friedman, Barbara Nemesure

  • 1Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794-7025, USA.

Indian Journal of Pathology & Microbiology
|September 22, 2011
PubMed
Summary

Geographic variations in pediatric solid malignant neoplasms (PSMNs) were observed. This study highlights differences in tumor types and frequencies between the US and India, underscoring the need for global awareness of PSMNs.

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Area of Science:

  • Pediatric Oncology
  • Epidemiology
  • Cancer Research

Background:

  • Pediatric solid malignant neoplasms (PSMNs) are a major cause of childhood mortality worldwide.
  • Understanding the epidemiological patterns of PSMNs is crucial for targeted interventions and improved outcomes.

Purpose of the Study:

  • To analyze the incidence and patterns of PSMNs at a US hospital.
  • To compare these findings with data from India and global registries.
  • To identify geographic variations in pediatric cancer types and frequencies.

Main Methods:

  • Retrospective review of 127 PSMN cases at Stony Brook University Medical Center (2000-2008).
  • Comparison with 101 PSMN cases from an Indian hospital (1975-1982) and global data.
  • Statistical analysis, including Fisher's Exact test, to assess significant differences.

Main Results:

  • The US cohort had a male to female ratio of 1.16:1 and a mean age of 4.8 years.
  • Central nervous system (CNS) and sympathetic nervous system (SNS) tumors were more frequent in the US compared to global registries.
  • The Indian cohort showed a higher male to female ratio (4:1) and different tumor category frequencies, with statistically significant differences in CNS tumors, lymphomas, and retinoblastomas.

Conclusions:

  • Significant geographic variations exist in the incidence and histology of pediatric solid malignant neoplasms.
  • Despite advances, PSMNs remain a critical and often fatal challenge in pediatric healthcare globally.