Through the looking glass: the discovery of supercoiled DNA
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1Department of Microbiology, University of Alabama, Birmingham 35294.
Trends in Biochemical Sciences
|May 1, 1990
Abstract:
The discovery of supercoiled DNA was first reported 25 years ago in a paper entitled, 'The Twisted Circular Form of Polyoma Viral DNA' by Vinograd, Lebowitz, Radloff, Watson and Laipis. This personal reflection describes the different experimental and conceptual processes that eventually led to the discovery as they actually occurred.