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[Migraine aura--vascular or neuronal disease?]
T S Olsen1, L Friberg, N A Lassen
1Bispebjerg Hospital, København, klinisk fysiologisk/nuklearmedicinsk afdeling.
Ugeskrift for Laeger
|May 21, 1990
Summary
Cerebral blood flow (CBF) reduction during migraine with aura (MA) may cause ischemia, challenging the neurogenic theory. Evidence suggests vasospasm and ischemia are key factors in MA neurological deficits.
Area of Science:
- Neuroscience
- Cerebrovascular Medicine
Context:
- Migraine with aura (MA) is characterized by transient neurological deficits.
- Cerebral blood flow (CBF) reduction occurs in affected brain regions during MA attacks.
Purpose:
- To investigate the cause of neurological deficits during MA.
- To differentiate between the vascular and neurogenic theories of MA.
Summary:
- CBF reduction during MA was initially thought to be modest (20-35%) and insufficient to cause ischemia, supporting the neurogenic theory of spreading depression.
- However, recent findings suggest CBF reduction may indeed be sufficient to cause ischemia.
- Persistent deficits, EEG abnormalities, and infarcts after MA support vascular dysfunction, specifically vasospasm and ischemia, as the cause.
Impact:
- This research reframes the understanding of MA pathophysiology.
- It highlights the critical role of vascular dysfunction in MA-related neurological symptoms and potential brain damage.