Related Experiment Video
Updated: May 29, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
Gastrointestinal stromal tumors of the stomach and duodenum
Philippe A Cassier1, Jean Yves Blay
1Departement de Médecine, Centre Léon Bérard, Lyon, France.
Purpose Of Review:
Gastrointestinal stromal tumors (GISTs) are rare, malignant neoplasms of the gastrointestinal tract which are in most cases driven by oncogenic mutation of KIT or PDGFRA. GISTs may arise anywhere along the gastrointestinal tract but the stomach is the most common primary location, whereas duodenal GISTs are rare. New data regarding the adjuvant treatment of these tumors were recently reported and are likely to impact patient management.
Recent Findings:
In this article, we review the diagnostic, prognostic and therapeutic specificities of gastric and duodenal GISTs. Also, specificities in the molecular biology of gastric and duodenal GISTs are discussed.
Summary:
Gastric GISTs are relatively frequent and recent data indicate that imatinib-resistant PDGFRA-D842V mutation may be found in up to 10% of cases of localized gastric GISTs and this impacts the prescription of adjuvant imatinib. Duodenal GISTs, on the contrary, are rare and have rather poor prognosis. Furthermore these tumors frequently harbor KIT exon 9 mutations for which the adequate dose of adjuvant imatinib is debated.
Related Concept Videos
Gross Anatomy of the Stomach
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Other Disorders of Digestive System
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastrointestinal Motility Disorders