Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Role of Fusobacterium nucleatum in the pathogenesis of oral squamous cell carcinoma: A systematic review of molecular mechanisms and signalling pathways" [Archives of Oral Biology 179 (2025) 106369].

Archives of oral biology·2025
Same author

Role of Fusobacterium nucleatum in the pathogenesis of oral squamous cell carcinoma: A systematic review of molecular mechanisms and signalling pathways.

Archives of oral biology·2025
Same author

ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute <i>Pseudomonas aeruginosa</i> Infection by Suppression of Inflammation Rather Than Microbial Killing.

Biomolecules·2022
Same author

The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway.

Journal of immunology (Baltimore, Md. : 1950)·2021

Related Experiment Video

Updated: May 29, 2026

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Peli1 (rel)ieves autoimmunity.

Paul N Moynagh

    Nature Immunology
    |September 22, 2011
    PubMed
    Summary
    This summary is machine-generated.

    The ubiquitin E3 ligase Peli1 prevents autoimmunity by regulating T cell activation. This finding highlights Peli1

    More Related Videos

    Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
    07:09

    Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

    Published on: January 7, 2019

    Related Experiment Videos

    Last Updated: May 29, 2026

    Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
    12:59

    Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

    Published on: September 26, 2013

    Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
    07:09

    Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

    Published on: January 7, 2019

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cellular Biology

    Background:

    • T cell tolerance is crucial for preventing autoimmune diseases.
    • Dysregulation of T cell activation can lead to self-reactivity.

    Discussion:

    • The ubiquitin E3 ligase Peli1 functions as a key negative regulator of T cell activation.
    • Peli1's role is vital in maintaining the delicate balance of self-tolerance.

    Key Insights:

    • Peli1 negatively regulates T cell activation.
    • Peli1 is essential for maintaining T cell tolerance and preventing autoimmunity.

    Outlook:

    • Further research into Peli1's mechanisms could reveal novel therapeutic targets for autoimmune disorders.
    • Understanding Peli1's role may offer new strategies for immune system modulation.