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Updated: May 29, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
Tailored optical force fields using evolutionary algorithms
Colin C Olson1, Ross T Schermer, Frank Bucholtz
1Naval Research Laboratory, Optical Sciences Division, Washington, D.C. 20375, USA. colin.olson.ctr@nrl.navy.mil
Abstract:
We introduce a method whereby the electromagnetic field that governs the force on a Rayleigh particle can be tailored such that the resultant force field conforms to a desired geometry. The electromagnetic field is expanded as a set of vector spherical wavefunctions (VSWFs) that describe the field over all space. Given the incident field, the resultant force on a given Rayleigh particle can be calculated throughout a volume of interest. We use an evolutionary algorithm (EA) to search the space of coefficients governing the VSWFs for those that produce the desired force field. We demonstrate how Maxwell's equations will support an "optical tunnel" that guides particles to a trap location while at the same time preventing particles outside the tunnel from approaching the trap. This result is of interest because the field is impressed throughout the domain; that is to say, once the field is generated, no additional control is required to guide the particles.
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