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Natural course of cow's milk allergy in children with atopic dermatitis

Jungmin Suh1, Hyeonyoung Lee, Jung Hyun Lee

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Environmental Health Center for Atopic Diseases, Seoul, Korea.

Journal of Korean Medical Science
|September 22, 2011
PubMed

Insights

Many children with atopic dermatitis (AD) and cow's milk allergy develop tolerance by age 67 months. Peak cow's milk-specific IgE levels in early childhood predict allergy outcomes.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Clinical Immunology

Background:

  • Cow's milk allergy (CMA) is a prevalent food allergy in children, particularly those with atopic dermatitis (AD).
  • Understanding the natural history and predictive factors of CMA in children with AD is crucial for clinical management.

Purpose of the Study:

  • To describe the natural course of cow's milk allergy in children diagnosed with atopic dermatitis.
  • To identify clinical characteristics and prognostic factors influencing the outcome of cow's milk allergy.

Main Methods:

  • Retrospective review of medical records for 115 children diagnosed with AD and CMA before 24 months of age.
  • Evaluation of clinical characteristics and prognostic factors over a follow-up period of 24 to 114 months.
  • Multivariate analysis using the Cox proportional hazard model to identify predictive factors.

Main Results:

  • The median age for developing tolerance to cow's milk was 67 months.
  • Half of the children achieved tolerance by this median age.
  • Peak cow's milk-specific IgE levels within the first 24 months of life were the most significant predictor of allergy outcome.

Conclusions:

  • Cow's milk allergy in children with AD often resolves, with a significant proportion achieving tolerance by mid-childhood.
  • Early-life peak cow's milk-specific IgE levels serve as a valuable tool for predicting the prognosis of CMA in this population.
  • This finding aids in managing expectations and guiding clinical follow-up for pediatric CMA.

Keywords:
Food HypersensitivityImmunoglobulin EMilkPrognosis

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